NSAIDs or Cox 2 Inhibitors?

As I have talked to more patients (new and existing), many people have expressed concern on their dependence on non-steroidal anti-inflammatory drugs, NSAIDs (aspirin, advil, motrin), and how they negatively affects their stomachs or digestion of foods.

Cyclooxygenase (COX) is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Some of these mediators are the precursors to pain-producing chemicals and are always found at sites where inflammation is present. Over-the-counter pain-relief drugs (Advil, Aspirin, Ibuprofen, etc) are COX inhibitors that stop the production of both COX-1 and COX-2.

COX-1 enzymes promote the production of the natural mucus lining that protects the inner stomach and contribute to reduced acid secretion and reduced pepsin content. This natural lining has a protective role in maintaining proper stomach/intestinal function.

COX-2 enzymes are responsible for inflammation and pain (what NSAIDs are designed to inhibit/stop!)

There are natural products that stop the production of COX-2 enzymes. A small list of these include:

  • green tea
  • ginger
  • basil
  • turmeric
  • garlic

The easiest way to add these to your diet is spice up your food to prevent pain and inflammation. Another great product is ZYFLAMEND. This all natural supplement is a proteolytic enzyme mixture that is used to prevent chronic pain and doesn’t affect COX-1 enzymes, so it has no gastrointestinal side effects. Each softgel contains natural rosemary, turmeric, ginger, holy basil, green tea and oregano already in it! Please ask us if this supplement can help you. Nature’s Nutrition in Drum Point Plaza (the corner of Drum Point Rd and Brick Blvd) carry this product and we all highly recommend it!

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